The gut – center of the immune system
The gut is far more than just a digestive organ – it is the center of our immune system. Over 70% of all immune cells are located here, and a healthy gut flora protects us daily from pathogens. But what happens when this delicate system gets out of balance? For people with histamine issues, gut health plays a key role: a compromised gut can not only weaken immune defense but also limit the breakdown of histamine. In this article, you will learn how the gut, immune system, and histamine are connected – and why targeted gut care can alleviate symptoms.
The gut as the control center of immune defense
70% of the immune system is located in the gut
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Training for immune cells:
Gut bacteria produce short-chain fatty acids like butyrate, which inhibit inflammation and "train" immune cells. Studies show: A diverse gut flora reduces the risk of autoimmune diseases and allergies. -
Barrier function:
The intestinal wall prevents harmful substances from entering the bloodstream. If this barrier is permeable ("Leaky Gut"), toxins and undigested food components can trigger inflammation.
Dysbiosis – When the microbiome gets out of balance
- An unbalanced diet (e.g., high sugar, low fiber)
- Chronic stress
- Medications such as antibiotics

- Weakening of the immune defense
- Chronic inflammation
- Histamine issues: Certain bacteria produce histamine themselves or block its breakdown.
Histamine intolerance: When the gut becomes the problem
DAO enzyme – The natural histamine degrader
- Skin redness, itching
- Headaches, migraines, dizziness
- Digestive issues (diarrhea, bloating)
Gut dysbiosis as a trigger
- Staphylococcus
- Enterobacteriaceae
- Excess histamine enters the blood through a weakened intestinal barrier.
- Chronic inflammation further inhibits DAO production.
- Histamine-related symptoms like skin rashes or digestive complaints intensify.

Probiotics for histamine issues: Targeted gut support
How probiotics can help
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Inhibiting histamine-producing bacteria:
Strains such as Lactobacillus rhamnosus GG and Bifidobacterium longum displace harmful germs. -
Strengthening the intestinal barrier:
Probiotics can promote the production of mucosal cells and close gaps in the intestinal epithelium. -
Anti-inflammatory effects:
Certain bacteria produce butyrate, which can reduce chronic inflammation.
Would you like to easily integrate selected bacterial strains into your daily routine? Our BioticFit S combines the three spore-based bacterial strains Bacillus subtilis, Bacillus coagulans, and Bacillus clausii. The formula is supplemented with acacia fiber and zinc. Zinc contributes, among other things, to the normal function of the immune system.
Thanks to the practical DR-capsules, BioticFit S can be easily integrated into your everyday life. It is suitable for a low-histamine & low-fructose diet, gluten-free, lactose-free, and vegan as well as free from unnecessary additives & lab-tested.
Tips for a healthy gut and a strong immune system despite histamine issues
Diet:
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Fiber:
At least 30 g daily (e.g., pumpkin seeds, oatmeal, vegetables) – they are food for good gut bacteria. -
Low-histamine foods:
Fresh vegetables (zucchini, broccoli), gluten-free grains (quinoa, rice), lean meat (as fresh as possible). -
Caution with fermented foods:
Sauerkraut or kimchi are probiotic, but are generally unsuitable for a low-histamine diet.
Stress management:
- Chronic stress can increase histamine levels and damage the intestinal barrier.
- Practical tips: Yoga, breathing exercises, or 10 minutes of daily meditation.
Conclusion: Gut health as the key to well-being
- Increase DAO activity
- Reduce chronic inflammation
- Alleviate symptoms like skin redness or digestive issues
This article is for general information purposes and does not replace medical advice. If you suspect histamine intolerance, please consult a physician or nutritionist.
Would you like to address the topics of the gut, intestinal lining, and histamine breakdown in your daily routine as well? Our DarmFit-Set combines three selected products for this purpose: Bio BioticFit with eight bacterial strains, MucosaFit containing L-glutamine, flaxseed, and selected vitamins and minerals, and DaoFit with vegan DAO from pea sprouts.
This way, you get the three products practically in one set without having to assemble them individually.
All included products are suitable for a low-histamine & low-fructose diet, gluten-free, lactose-free, and vegan as well as free from unnecessary additives & lab-tested.
Lieferzeit: 2-3 Tage
Sources
- Maintz, L. & Novak, N. (2007). Histamine and histamine intolerance. The American Journal of Clinical Nutrition.
- Schink, M. et al. (2018). Microbial patterns in patients with histamine intolerance. Journal of Physiology and Pharmacology.
- Sánchez-Pérez et al. (2022). Intestinal Dysbiosis in Patients with Histamine Intolerance. Nutrients. (PMC9102523)
- EU Regulation on health claims (No. 432/2012).
