Estrogen dominance and histamine intolerance
Did you know that our hormones can have a major influence on histamine metabolism? The topic of estrogen dominance is particularly interesting in this regard. Today, we would like to explain to you why this is the case.
What do estrogen and progesterone do?
Estrogens are (the most important) female sex hormones, which fluctuate with the hormone progesterone and can constantly change in concentration. This depends on various factors such as age, the menstrual cycle, and also dietary habits. Estrogens control the monthly menstrual cycle, as they promote the buildup of the uterine lining as well as the growth of breast tissue, skin, and hair. Furthermore, estrogen inhibits bone resorption and increases blood clotting.
Progesterone plays a significant role especially in the second half of the cycle, as this is when the hormone is increasingly produced. Its purpose is to prepare the uterus for an impending pregnancy. In addition, progesterone triggers thyroid activation, counteracts cellulite and wrinkle formation, and ensures bone stability. If the progesterone level is too low, estrogen dominance occurs.
What is estrogen dominance?
The term estrogen dominance is essentially used to describe a state in the body in which the estrogen level is generally higher than normal. This primarily affects women during menopause, but estrogen dominance can also occur in young women – and even in men.
What can be the causes of estrogen dominance?
Estrogen dominance can have many causes. As just mentioned, menopause can often be responsible for it. However, diet can also play a major role, as can obesity, contraceptives, or a mineral imbalance.
During menopause, the female body changes its entire hormonal structure. The ovaries stop their hormone production, and progesterone is no longer needed as much. This is how a typical estrogen dominance arises. This happens due to cycles without ovulation.
Hormonal contraceptives have various effects on the body – ovulation is prevented, fertilization of the egg cell does not take place, and the uterine lining is altered. Most hormonal contraceptives contain progestins, which influence our hormonal system and disrupt hormone production.
Nutrition is not only particularly important for histamine intolerance or the prevention of diseases, but is actually sometimes also responsible for our hormonal balance. There are some foods that can help you to somewhat balance hormonal imbalances. Conversely, there are also foods that reinforce a dysbalance. For example, soy can have an estrogenic effect (soy should be avoided in the case of histaminosis anyway).
How can I recognize estrogen dominance?
Recognizing estrogen dominance on your own is difficult because the symptoms can be very diverse:
- Irregular or otherwise abnormal menstruation
- Water retention or a bloated feeling
- PMS symptoms
- Thyroid problems
- Mood swings
- Headaches or migraines (often premenstrual)
- Weight gain
- Sleep disorders
- Fatigue, exhaustion
- Histamine intolerance
For this reason, it is very important to have a potential estrogen dominance clarified by a doctor.
What is the connection between estrogen dominance and histamine intolerance?

IMPORTANT: An increased histamine level in the body can accompany estrogen dominance, which is why it can be the case that symptoms of histamine intolerance occur more intensely, especially at the beginning of menstruation and at the time of ovulation.
How can I deal with estrogen dominance?
You can counteract estrogen dominance with herbal remedies or hormones. However, we recommend that you first have a doctor determine whether there is actually an excess or a deficiency, and to what extent.
Here are our 5 tips on what else you can do in case of estrogen dominance:
- Make an appointment with an endocrinologist (specialist for hormones) and clarify whether estrogen dominance is present
- If you have received a positive diagnosis, follow a 100% low-histamine diet
- A nutrient deficiency can disrupt the balance of the hormonal system. Ensure an adequate supply to support your hormonal balance. A blood test at the doctor's office can provide information about potential nutrient deficiencies.
- Plants like maca, chasteberry, yarrow, or wild yam are also used traditionally – you should be cautious with chasteberry and MCAS!
- Care for your gut with plenty of good dietary fiber and probiotic cultures. A gut cleanse would also be recommended
A good supply of nutrients can play an important role in everyday female life. Our FemFit was developed by women for women and combines vitamin B6 with magnesium, calcium, iron, and L-tryptophan as well as selected plants such as lady's mantle, chasteberry, yarrow, and ashwagandha. Particularly relevant to the topic: Vitamin B6 contributes to the regulation of hormonal activity. A well-thought-out combination for your daily routine.
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