Is acquired histamine intolerance curable?
When addressing the question of whether a histamine intolerance is curable, many sufferers are asked by non-sufferers: "Isn't there an immunization against it?". We all know that only allergies can be immunized. Are the symptoms and chances of recovery for histamine intolerance similar to those of an allergy? In this blog post, we'll clarify whether there are chances of recovery and, if so, how you can achieve this goal.
Histamine Intolerance: Allergy or Pseudoallergy?
According to some sources, food intolerances like histaminosis are incurable. But is that really true? Food allergies are caused by a faulty reaction of the immune system, which develops antibodies against certain food components like proteins. Even the smallest amounts can lead to an anaphylactic shock.
If, on the other hand, you suffer from a food intolerance, your body is unable to digest certain food components. The disturbed digestive process results from missing transport substances and enzymes in the intestine. Depending on the person, the tolerance limit is individual. Some people can consume a larger amount of an incompatible food than others. Histamine intolerance occupies a special position.
The term "intolerance" falsely suggests an intolerance in the true sense, such as lactose intolerance. However, if you suffer from what is beautifully called in the literature a food-induced histaminosis, anaphylaxis can occur, just as with allergies.

Histamine and Healing: Do They Go Together?
Histamine and Its Functions
Histamine is not only found in food but also contributes to healing as an endogenous substance. Histamine is involved in the following essential processes in your body, among others:
- Regulation of the sleep-wake rhythm
- Appetite regulation as a neurotransmitter
- Control of thought processes
- Regulation of water balance
- Vasodilation for nutrient transport
- Defense against foreign substances
- Support of healing processes
- Formation of lactic acid
- Blood pressure regulation
- Resolution of inflammation
If your body no longer breaks down histamine properly or produces too much histamine, a derailed histamine metabolism is present.
How does histamine breakdown work in the body?
Two enzymes regulate histamine breakdown: on the one hand, the enzyme diamine oxidase (DAO), and on the other hand, N-methyltransferase. DAO production occurs, among other places, in the intestinal lining, while N-methyltransferase is produced in the liver. Insufficient histamine-degrading enzymes can be formed if there is inadequate liver or intestinal function or if you lack important micronutrients.
The result is a non-functional regulation of your body's own histamine. If you then also consume histamine-containing foods, the so-called "histamine barrel" quickly overflows.
Since histamine breakdown is closely linked to a healthy intestinal mucosa, it can be useful to specifically support it. Our MucosaFit contains, among other things, biotin and niacin, which contribute to the maintenance of normal mucous membranes. The formula is supplemented with L-glutamine, fennel, flaxseed, and other selected vitamins and minerals. MucosaFit is suitable for a low-histamine, low-fructose, gluten-free, and lactose-free diet. Additionally, it is vegan, laboratory-tested, and free of unnecessary additives.
5 Steps to More Freedom from Symptoms
The basis for the entire treatment process is always the cause of the histaminosis, which is individual for each patient. Only in this way can histamine intolerance be effectively addressed. Often, sufferers experience nutrient deficiencies and an imbalance in their gut flora. We have helpful tips for you to make your everyday life with histamine intolerance more comfortable and symptom-free.
TIP: Your mental health plays a crucial role in your recovery. We recommend relaxation and breathing exercises, yoga, or meditation for stress reduction. All techniques can be wonderfully combined.

Step 1: Get a diagnosis
The first step should actually be self-explanatory. Only those who know their diagnosis and its causes can treat the illness effectively. However, many sufferers often only find out what they are suffering from years later, after their histamine intolerance has worsened.
This is due to the rather non-specific symptoms such as skin rashes, gastrointestinal complaints, heart palpitations, dizziness, or depressive moods, which are associated with other diseases. In some cases, histamine intolerance is also an accompanying symptom of irritable bowel syndrome. There is no 100% conclusive diagnostic procedure yet, as DAO determination in blood, urine, or stool is only a snapshot.
Step 2: Eat a low-histamine diet
An exclusion diet with low-histamine foods and a food-symptom diary are recommended, in which you record daily what you have eaten and how you tolerated the foods. You should avoid histamine-containing foods such as aged cheese or meat products, sauerkraut, tomatoes, or red wine, as well as histamine liberators. These cause your body to release histamine itself as a result of mast cell activation. These include, among others
- certain types of yeast
- seafood
- cocoa
- caffeine
- citrus fruits
- spinach
- arugula
Step 3: Drink enough water
It is essential, especially with histamine intolerance, to drink plenty of water. This regulates histamine function and promotes histamine breakdown. Dehydration, on the other hand, stimulates the body's own histamine production.
Still mineral water is best, as carbonated water is often not tolerated by those with histamine intolerance. If you drink tap water, you should use a filter to remove limescale, heavy metals, microplastics, and pesticides.
Step 4: Combat chronic inflammation
A diseased gut or other causes of histamine intolerance predispose to inflammation. Chronic inflammatory foci, in turn, lead to increased histamine release. To support the immune system, micronutrients such as vitamin C, zinc, iron, vitamin B12, folate, selenium, and vitamin D are recommended.
Step 5: Building up gut microbiome and mucous membrane
A healthy microbiome supplies your intestinal mucosa with all the necessary nutrients that contribute to optimal function. A strengthened intestinal mucosa, in turn, produces a sufficient amount of DAO and supports the breakdown of histamine from food.
ATTENTION: Antihistamines are not a solution and do not combat the cause of histaminosis. They can provide relief in an emergency, but long-term use can damage your intestinal lining and strain your liver. Always discuss the use of an antihistamine with a doctor or pharmacist.
A healthy gut microbiome plays an important role for many sufferers. Our BioticFit S contains three spore-based bacterial strains, acacia fiber, and zinc. Zinc contributes to the normal function of the immune system. Thanks to the gastric acid-resistant DR capsules, BioticFit S is ideal as a supplement to a low-histamine, low-fructose, gluten-free, and lactose-free diet. It is also vegan and free from unnecessary additives.
Is histamine intolerance curable? ─ Our conclusion
We at HistaFood believe that no one has to resign themselves to a diagnosis of histamine intolerance. Therapy concepts such as a permanent low-histamine diet and lifelong abstinence are not a solution. If you do not eat a balanced and varied diet, perhaps have other intolerances, and additionally live a vegan lifestyle, a pronounced nutrient deficiency can quickly arise, and you will enter an undesirable cycle of histamine-promoting factors.
Because many nutrients like vitamin C, magnesium, or vitamin B6 support your metabolism and contribute to a normal immune system function. Healing occurs at the root, namely the cause: If you manage to strengthen, build up, and detoxify your gut and liver, and specifically compensate for nutrient deficiencies, you have good chances of getting your histaminosis under control and becoming symptom-free.
Some sufferers of acquired histamine intolerance, unlike patients with genetic histamine intolerance, even manage to achieve complete freedom from symptoms despite a histamine-containing diet. However, patience is key, because don't forget: the longer your body has been out of balance, the longer it will take to rebuild.
Sources
- Dr. med. Fleck, Anne (2021): Energy! Der gesunde Weg aus dem Müdigkeitslabyrinth – Mit 30-Tage-Selbsthilfeprogramm.
- Kauffmann, Kyra/Kauffmann, Sascha (2021): Der Histamin-Irrtum: Weg von Radikaldiäten und Verbotslisten - die Formel für ein gesundes Leben mit Histamin.
- Králová, Dominika (2019): Sensible Bäuche essen anders: Die besten Gerichte und Tipps bei Unverträglichkeiten, Reizdarm und anderen Verdauungsbeschwerden.
- Schweigler, Dirk (2020): Histaminintoleranz aus einem völlig neuen Blickwinkel.
- Erfahrungsheilkunde Histaminintoleranz
- SIGHI-Liste - Kulifein.de
